Fleet Phospho-Soda
Phospho-soda is a non-prescription saline laxative that was produced by the Virginia-based C.B. Fleet Company. Consisting mostly of dibasic sodium phosphate heptahydrate and monobasic sodium phosphate monohydrate, the Fleet phospho-soda was often administered in two 45 ml doses to prepare the patient for colonoscopy. Around 45 ml of the substance is usually mixed with water or other carbonated drinks like ginger ale before consumption. Within 30 minutes to 6 hours after it is taken, the preparation usually results in bowel movement. To make it more palatable, Fleet phospho-soda comes in many flavors.
Problems Associated with the Usage of Fleet Phospho-Soda
Phospho-soda has been known to cause a serious kidney injury known as acute phosphate nephropathy, which is associated with calcium phosphate crystal deposits in the renal tubules. This may lead to permanent impairment of the renal function. Compared to polyethylene glycol-based laxatives, phospho-soda may worsen renal impairment. Since the 1990s, Fleet phospho-soda have been linked to kidney damage incidents. On 11 December 2008, the US Food and Drug Administration issued a Safety Report stating that it has become aware of reports of acute phosphate nephropathy associated with the use of oral sodium phosphate products. According to FDA, these products include prescription and over-the-counter laxatives. The agency has been concerned about the risks of using oral sodium phosphate products like Fleet phospho-soda available over-the-counter. When higher doses for cleansing the bowels were used, it is said to cause severe complications. Fleet recalled its phospho-soda products following the FDA alert.
Phospho-soda can be used as an ordinary laxative, but it is not advisable. It is best to use it by cutting the dosage by half and it ought to be used only once instead of twice. Its mechanism of action lies in drawing liquid to the colon. If not used properly, it can cause severe dehydration. That is why it is best administered with a physician’s knowledge and supervision. When taken for colonoscopy preparation, the dosage of Fleet phospho-soda is 45 ml, twice daily, taken six hours apart. A very loose or liquid stool will be produced within 30 minutes to 6 hours after taking the drug. A clinical study conducted in 2007 revealed that Fleet phospho-soda may worsen the renal condition of patients who have decreased renal function prior to drug administration. No difference was observed, however, in patients without kidney problems.
Lawsuits alleging renal injury from the use of Fleet phospho-soda have filled the state and federal courts since 2004. All these lawsuits were consolidated to the Northern District of Ohio. The DangerousDrugs.us website contains additional information about phospho-soda lawsuits.